The well-being of guests is top of mind at Choice-branded hotels. Guests may experience a variety of new, improved cleanliness protocols and products. Behind every great day is a great night at the Comfort Inn and Suites hotel in Orangeburg, SC. Located off Interstate 26, we are just ten minutes from South Carolina State University, and 30 minutes from Columbia Metropolitan Airport. Business-friendly amenities include a business center and meeting room that accommodates up to 25 people, as well as free WiFi, free hot breakfast, a fitness center and indoor heated pool. Each guestroom features a HDTV, refrigerator, microwave, coffee maker, work desk, iron and ironing board. Some rooms have kitchenettes and sofa-sleepers, too. Also, earn rewards including free nights and gift cards with our Choice Privileges Rewards program.