The well-being of guests is top of mind at Choice-branded hotels. Guests may experience a variety of new, improved cleanliness protocols and products. Behind every great day is a great night at the Comfort Inn Indianapolis South I-65 hotel in Indianapolis, IN. Located south of downtown, we are an easy drive to the Indianapolis International Airport. Our business travelers get rested and ready with complimentary amenities like free WiFi, daily hot breakfast, weekday newspaper and a fitness center. All guestrooms are furnished with flat-screen TVs, hair dryers and coffee makers. Select rooms include a hot tubs, microwaves, refrigerators and sofa-sleepers. Also, earn rewards including free nights and gift cards with our Choice Privileges Rewards program.