Stay awhile at the 100% smoke-free MainStay Suites® Orange County John Wayne Airport extended stay hotel in Santa Ana, CA. We're conveniently located right off State Route 55, just 10 minutes from John Wayne Airport. Whether you're planning to stay for a few days, weeks, months or longer, our carefully curated amenities and accommodations help you maintain your lifestyle. Enjoy free WiFi throughout the hotel and free parking during the length of your stay. Flying into John Wayne Airport? Take advantage of our free airport shuttle. You'll also enjoy the convenience of our onsite gift shop, our friendly 24-hour reception, and our guest laundry room. Showcasing an unbeatable location between I-5 and I-405, with quick access to Orange County businesses and attractions.