The newly renovated Holiday Inn Express & Suites San Diego - Otay Mesa welcomes you! This San Diego hotel offers a convenient suburban location in the heart of the Otay Mesa Industrial Business Park, a short drive from downtown San Diego and less than a mile from Tijuana, Mexico. We're also close to the Cross Border Xpress, North Island Credit Union Amphitheatre, SeaWorld Aquatica, SeaWorld, the Chula Vista Olympic Training Park, and the San Diego Zoo. Explore local history at the Cabrillo National Monument, the Air and Space Museum, and the Maritime Museum, or visit during annual events like Comic-Con. Enjoy shopping at Las Americas Premium Outlets, with 125 stores and 13 restaurants, or the nearby Otay Town Center Mall. Business travelers appreciate our proximity to companies like Toyota, Bose, Panasonic, and Samsung, all within six miles in the Otay Mesa Industrial Park. The International Commercial Border Crossing is just a quarter-mile away, and Brown Field Municipal Airport is three miles away. During your stay, enjoy our complimentary hot breakfast, fitness center, and outdoor pool. Check out our room deals to start planning your trip!